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Consensus Based Definition of Growth Restriction in the Newborn

Lookup NU author(s): Professor Nicholas EmbletonORCiD


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© 2017 Elsevier Inc. Objective: To develop a consensus definition of growth restriction in the newborn that can be used clinically to identify newborn infants at risk and in research to harmonize reporting and definition in the current absence of a gold standard. Study design: An international panel of pediatric leaders in the field of neonatal growth were invited to participate in an electronic Delphi procedure using standardized methods and predefined consensus rules. Responses were fed back at group-level and the list of participants was provided. Nonresponders were excluded from subsequent rounds. In the first round, variables were scored on a 5-point Likert scale; in subsequent rounds, inclusion of variables and cut-offs were determined with a 70% level of agreement. In the final round participants selected the ultimate algorithm. Results: In total, 57 experts participated in the first round; 79% completed the procedure. Consensus was reached on the following definition: birth weight less than the third percentile, or 3 out of the following: birth weight <10th percentile; head circumference <10th percentile; length <10th percentile; prenatal diagnosis of fetal growth restriction; and maternal pregnancy information. Conclusions: Consensus was reached on a definition for growth restriction in the newborn. This definition recognizes that infants with birth weights <10th percentile may not be growth restricted and that infants with birth weights >10th percentile can be growth restricted. This definition can be adopted in clinical practice and in clinical trials to better focus on newborns at risk, and is complementary to the previously determined definition of fetal growth restriction.

Publication metadata

Author(s): Beune IM, Bloomfield FH, Ganzevoort W, Embleton ND, Rozance PJ, van Wassenaer-Leemhuis AG, Wynia K, Gordijn SJ

Publication type: Article

Publication status: Published

Journal: The Journal of Pediatrics

Year: 2018

Volume: 196

Pages: 71-76

Print publication date: 01/05/2018

Online publication date: 28/02/2017

Acceptance date: 19/12/2017

ISSN (print): 0022-3476

ISSN (electronic): 1097-6833

Publisher: Mosby Inc.


DOI: 10.1016/j.jpeds.2017.12.059


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