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Lookup NU author(s): Professor Mike Waring
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexpeptides in combination with a bacterial reverse two-hybrid system. This cyclic peptide is shown to bind the BTB domain of BCL6, disrupts its homodimerization, and subsequent binding of the SMRT2 corepressor peptide.
Author(s): Osher EL, Castillo F, Elumalai N, Waring MJ, Pairaudeau G, Tavassoli A
Publication type: Article
Publication status: Published
Journal: Bioorganic & Medicinal Chemistry
Print publication date: 15/07/2018
Online publication date: 09/03/2018
Acceptance date: 07/03/2018
Date deposited: 15/03/2018
ISSN (print): 0968-0896
ISSN (electronic): 1464-3391
Publisher: Pergamon Press
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