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Lookup NU author(s): Dr David Wilkinson, Dr Maria Arques Mengual, Emeritus Professor Drew Rowan
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© 2018 The British Pharmacological Society. Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer and arthritis failed clinically, primarily due to poor selectivity for target MMPs. In recent years, roles for serine proteinases in the proteolytic cascades leading to cartilage destruction have become increasingly apparent, renewing interest in the potential for new therapeutic strategies that utilize pharmacological inhibitors against this class of proteinases. Herein, we describe key serine proteinases with likely importance in arthritic disease and highlight recent advances in this field.
Author(s): Wilkinson DJ, Arques MdC, Huesa C, Rowan AD
Publication type: Article
Publication status: Published
Journal: British Journal of Pharmacology
Year: 2018
Volume: 176
Issue: 1
Pages: 38-51
Print publication date: 01/01/2019
Online publication date: 23/02/2018
Acceptance date: 09/02/2018
ISSN (print): 0007-1188
ISSN (electronic): 1476-5381
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1111/bph.14173
DOI: 10.1111/bph.14173
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