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Lookup NU author(s): Dr Samy Rima
This is the final published version of an article that has been published in its final definitive form by Elsevier Ltd, 2014.
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Monkey electrophysiology [1, 2] suggests that the activity of the ventral tegmental area (VTA) helps regulate reinforcement learning and motivated behavior, in part by broadcasting prediction error signals throughout the reward system. However, electrophysiological studies do not allow causal inferences regarding the activity of VTA neurons with respect to these processes because they require artificial manipulation of neuronal firing. Rodent studies fulfilled this requirement by demonstrating that electrical and optogenetic VTA stimulation can induce learning and modulate downstream structures [3-7]. Still, the primate dopamine system has diverged significantly from that of rodents, exhibiting greatly expanded and uniquely distributed cortical and subcortical innervation patterns [8]. Here, we bridge the gap between rodent perturbation studies and monkey electrophysiology using chronic electrical microstimulation of macaque VTA (VTA-EM). VTA-EM was found to reinforce cue selection in an operant task and to motivate future cue selection using a Pavlovian paradigm. Moreover, by combining VTA-EM with concurrent fMRI, we demonstrated that VTA-EM increased fMRI activity throughout most of the dopaminergic reward system. These results establish a causative role for primate VTA in regulating stimulus-specific reinforcement and motivation as well as in modulating activity throughout the reward system. ?? 2014 Elsevier Ltd.
Author(s): Arsenault JT, Rima S, Stemmann H, Vanduffel W
Publication type: Article
Publication status: Published
Journal: Current Biology
Year: 2014
Volume: 24
Issue: 12
Pages: 1347-1353
Print publication date: 16/06/2014
Online publication date: 29/05/2014
Acceptance date: 22/04/2014
Date deposited: 24/04/2018
ISSN (print): 0960-9822
ISSN (electronic): 1879-0445
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.cub.2014.04.044
DOI: 10.1016/j.cub.2014.04.044
PubMed id: 24881876
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