Toggle Main Menu Toggle Search

Open Access padlockePrints

Origins of lifetime health around the time of conception: causes and consequences

Lookup NU author(s): Dr Miguel Velazquez, Professor John Mathers

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their lives, as captured in the Developmental Origins of Health and Disease concept. Research across the epidemiological, clinical, and basic science fields has identified the period around conception as being crucial for the processes mediating parental influences on the health of the next generation. During this time, from the maturation of gametes through to early embryonic development, parental lifestyle can adversely influence long-term risks of offspring cardiovascular, metabolic, immune, and neurological morbidities, often termed developmental programming. We review periconceptional induction of disease risk from four broad exposures: maternal overnutrition and obesity; maternal undernutrition; related paternal factors; and the use of assisted reproductive treatment. Studies in both humans and animal models have demonstrated the underlying biological mechanisms, including epigenetic, cellular, physiological, and metabolic processes. We also present a meta-analysis of mouse paternal and maternal protein undernutrition that suggests distinct parental periconceptional contributions to postnatal outcomes. We propose that the evidence for periconceptional effects on lifetime health is now so compelling that it calls for new guidance on parental preparation for pregnancy, beginning before conception, to protect the health of offspring.


Publication metadata

Author(s): Fleming TP, Watkins AJ, Velazquez MA, Mathers JC, Prentice AM, Stephenson J, Barker M, Saffery R, Yajnik CS, Eckert JJ, Hanson MA, Forrester T, Gluckman PD, Godfrey KM

Publication type: Review

Publication status: Published

Journal: The Lancet

Year: 2018

Volume: 391

Issue: 10132

Pages: 1842-1852

Print publication date: 07/05/2018

Online publication date: 16/04/2018

Acceptance date: 31/01/2018

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

URL: https://doi.org/10.1016/s0140-6736(18)30312-x

DOI: 10.1016/s0140-6736(18)30312-x

PubMed id: 29673874


Share