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Thyroid Hormones and Cardiovascular Function and Diseases

Lookup NU author(s): Dr Salman Razvi, Dr Avais Jabbar, Professor Azfar Zaman

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality. Experimental data and small clinical trials have suggested a beneficial role of TH in ameliorating CV disease. The aim of this review is to provide clinicians dealing with CV conditions with an overview of the current knowledge of TH perturbations in CV disease.


Publication metadata

Author(s): Razvi S, Jabbar A, Pingitore A, Danzi S, Biondi B, Klein I, Peeters R, Zaman A, Iervasi G

Publication type: Review

Publication status: Published

Journal: Journal of the American College of Cardiology

Year: 2018

Volume: 71

Issue: 16

Pages: 1781-1796

Print publication date: 24/04/2018

Online publication date: 16/04/2018

Acceptance date: 13/02/2018

ISSN (print): 0735-1097

ISSN (electronic): 1558-3597

Publisher: Elsevier

URL: https://doi.org/10.1016/j.jacc.2018.02.045

DOI: 10.1016/j.jacc.2018.02.045


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