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Design and modelling of an engineered bacteria-based, pressure-sensitive soil.

Lookup NU author(s): Professor Martyn Dade-Robertson, Dr Helen Mitrani, Dr Luis Hernandez-Hernandez, Dr Aurelie Guyet, Professor Anil Wipat



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


In this paper, we describe the first steps in the design of a synthetic biological system based on the use of genetically modified bacteria to detect elevated pressures in soils and respond by cementing soil particles. Such a system might, for example, enable a self‐ constructed foundation to form in response to load using engineered bacteria which could be seeded and grown in the soils. This process would reduce the need for large‐scale excavations and may be the basis for a new generation of self‐assembling and responsive bio‐based materials. A prototype computational model is presented which integrates experimental data from a pressure sensitive gene within Escherichia coli bacteria with geotechnical models of soil loading and pore water pressure. The results from the integrated model are visualised by mapping expected gene expression values onto the soil volume. We also use our experimental data to design a two component system where one type of bacteria acts as a sensor and signals to another material synthesis bacteria. The simulation demonstrates the potential of computational models which integrate multiple scales from macro stresses in soils to the expression of individual genes to inform new types of design process. The work also illustrates the combination of in silico (silicon based computing) computation with in vivo (in the living) computation.

Publication metadata

Author(s): Dade-Robertson M, Mitrani H, Rodriguez-Corral J, Zhang M, Hernan L, Guyet A, Wipat A

Publication type: Article

Publication status: Published

Journal: Bioinspiration & Biomimetics

Year: 2018

Volume: 13

Issue: 4

Print publication date: 24/05/2018

Online publication date: 13/04/2018

Acceptance date: 13/04/2018

Date deposited: 21/05/2018

ISSN (print): 1748-3182

ISSN (electronic): 1748-3190

Publisher: Institute of Physics Publishing Ltd.


DOI: 10.1088/1748-3190/aabe15


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