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Risk of cardiomyopathy and cardiac arrhythmias in patients with nonalcoholic fatty liver disease

Lookup NU author(s): Professor Quentin AnsteeORCiD


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© 2018 Macmillan Publishers Ltd., part of Springer Nature Nonalcoholic fatty liver disease (NAFLD) is a common, progressive liver disease that affects up to one-quarter of the adult population worldwide. The clinical and economic burden of NAFLD is mainly due to liver-related morbidity and mortality (nonalcoholic steatohepatitis, cirrhosis or hepatocellular carcinoma) and an increased risk of developing fatal and nonfatal cardiovascular disease, chronic kidney disease and certain types of extrahepatic cancers (for example, colorectal cancer and breast cancer). Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects. This Review focuses on the association between NAFLD and non-ischaemia-related cardiac disease, discusses the putative pathophysiological mechanisms and briefly summarizes current treatment options for NAFLD that might also beneficially affect cardiac disease.

Publication metadata

Author(s): Anstee QM, Mantovani A, Tilg H, Targher G

Publication type: Article

Publication status: Published

Journal: Nature Reviews Gastroenterology and Hepatology

Year: 2018

Volume: 15

Pages: 425-439

Online publication date: 30/04/2018

Acceptance date: 02/04/2018

ISSN (print): 1759-5045

ISSN (electronic): 1759-5053

Publisher: Nature Publishing Group


DOI: 10.1038/s41575-018-0010-0


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