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Lookup NU author(s): Dr Matthew Jackson,
Dr David Austin,
Dr Mark De Belder,
Professor Azfar Zaman
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© 2018 Wiley Periodicals, Inc. Objectives: To study the relationship between diabetes mellitus (DM) and left ventricular (LV) function on outcomes following percutaneous coronary intervention (PCI). Background: DM is a growing public health challenge worldwide and a significant risk factor for cardiovascular disease and heart failure. Methods: All PCI procedures performed between 2006 and 2013 with LV function and diabetic status recorded in the BCIS-NICOR database were included. Demographic, procedural, and clinical outcomes data were collected. Multivariable logistic regression was used to provide adjusted estimates of clinical outcome by LV function and DM, including DM sub-type. Results: Of 260,726 patients, DM was present in 52,160 (20%); moderate LV systolic dysfunction (LVSD) was present in 51,266 (20%), and severe LVSD in 18,148 (7%). Worsening LVSD in diabetic patients was associated with poorer prognosis following PCI; moderate LVSD odds ratio (OR) 2.03 (95% CI 1.72-2.38) and severe LVSD OR 4.17 (95% CI 3.52-4.93). There was a higher crude and adjusted mortality rate for patients with DM across all grades of LVSD. However, the relative effect of DM appeared attenuated in the severe LVSD group compared with moderate or good LV function, particularly evident in patients with insulin requiring DM (good LV OR 2.09 [95% CI 1.66-2.65]; moderate LVSD OR 1.56 [95% CI 1.26-1.93], poor LV OR 1.40 [95% CI 1.13-1.74]). Conclusions: DM was associated with increased 30-day mortality for all grades of LV function. The prognostic impact of DM was strongest in patients with normal LV function and less evident in patients with severe LV systolic dysfunction.
Author(s): Jackson M, Austin D, Kwok CS, Rashid M, Kontopantelis E, Ludman P, de Belder M, Mamas MA, Zaman A
Publication type: Article
Publication status: Published
Journal: Catheterization and Cardiovascular Interventions
Print publication date: 15/11/2018
Online publication date: 04/05/2018
Acceptance date: 27/03/2018
ISSN (print): 1522-1946
ISSN (electronic): 1522-726X
Publisher: John Wiley and Sons Inc.
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