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Outcomes of lung transplantation in adults with bronchiectasis

Lookup NU author(s): Dr Jodie Birch, Dr Katy Hester, Dr Gareth Parry, Professor Kate Gould, Professor John Dark, Stephen Clark, Dr Gerard Meachery, Dr James Lordan, Professor Andrew FisherORCiD, Emeritus Professor Nick Europe-Finner, Professor Anthony De SoyzaORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2018 The Author(s). Background: Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. Methods: A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. Results: Fourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation. Mean age at transplantation was 47.1 years. Pre-transplantation osteoporosis was a significant non-pulmonary morbidity (48%). Polymicrobial infection was common, with Pseudomonas aeruginosa infection frequently but not universally observed (67%). Forced expiratory volume in 1 second (% predicted) improved from a pre-transplantation mean of 0.71 L (22% predicted) to 2.56 L (79 % predicted) at 1-year post-transplantation. Our survival results were 74% at 1 year, 64% at 3 years, 61% at 5 years and 48% at 10 years. Sepsis was a common cause of early post-transplantation deaths. Conclusions: Lung transplantation for end-stage BR is a useful therapeutic option, with good survival and lung function outcomes. Survival values were similar to other bilateral lung transplants at our centre. Pre-transplantation Pseudomonas infection is common.

Publication metadata

Author(s): Birch J, Sunny SS, Hester KLM, Parry G, Kate Gould F, Dark JH, Clark SC, Meachery G, Lordan J, Fisher AJ, Corris PA, De Soyza A

Publication type: Article

Publication status: Published

Journal: BMC Pulmonary Medicine

Year: 2018

Volume: 18

Online publication date: 22/05/2018

Acceptance date: 25/04/2018

Date deposited: 04/06/2018

ISSN (electronic): 1471-2466

Publisher: BioMed Central Ltd


DOI: 10.1186/s12890-018-0634-4


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