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Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons

Lookup NU author(s): Dr Seva TelezhkinORCiD, Dr Polina YarovaORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2018 The Author(s)Kv7 channels determine the resting membrane potential of neurons and regulate their excitability. Even though dysfunction of Kv7 channels has been linked to several debilitating childhood neuronal disorders, the ontogeny of the constituent genes, which encode Kv7 channels (KNCQ), and expression of their subunits have been largely unexplored. Here, we show that developmentally regulated expression of specific KCNQ mRNA and Kv7 channel subunits in mouse and human striatum is crucial to the functional maturation of mouse striatal neurons and human-induced pluripotent stem cell-derived neurons. This demonstrates their pivotal role in normal development and maturation, the knowledge of which can now be harnessed to synchronise and accelerate neuronal differentiation of stem cell-derived neurons, enhancing their utility for disease modelling and drug discovery.

Publication metadata

Author(s): Telezhkin V, Straccia M, Yarova P, Pardo M, Yung S, Vinh N-N, Hancock JM, Barriga GG-D, Brown DA, Rosser AE, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ

Publication type: Article

Publication status: Published

Journal: Pflugers Archiv European Journal of Physiology

Year: 2018

Volume: 470

Pages: 1359-1376

Online publication date: 24/05/2018

Acceptance date: 15/05/2018

Date deposited: 05/06/2018

ISSN (print): 0031-6768

ISSN (electronic): 1432-2013

Publisher: Springer Verlag

URL: https://doi.org/10.1007/s00424-018-2155-7

DOI: 10.1007/s00424-018-2155-7

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