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Translational gaps in animal models of human infusion reactions to nanomedicines

Lookup NU author(s): Professor Moein MoghimiORCiD

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Abstract

© 2018 Future Medicine Ltd. Adverse infusion reactions to regulatory approved nanomedicines in human subjects are idiosyncratic, but outwardly reproducible in pigs. A large body of evidence suggests that the porcine reactions are related to robust nanoparticle clearance by pulmonary intravascular macrophages (PIMs), and rapid release of arachidonate metabolites from these cells. Similar to pigs, other animals that have resident PIMs in their lungs also respond to intravenously injected particles, where rapid particle clearance by PIMs correlate with peak periods of cardiopulmonary distress. Normal human lungs, however, do not have PIMs, but 'induced' PIMs have been identified in pulmonary circulation under certain pathological conditions. We question suitability, and limitation of these preclinical models for global assessment of nanomedicine safety, and discuss alternative models and approaches.

Publication metadata

Author(s): Moghimi SM, Simberg D

Publication type: Review

Publication status: Published

Journal: Nanomedicine

Year: 2018

Volume: 13

Issue: 9

Pages: 973-975

Online publication date: 23/05/2018

Acceptance date: 02/04/2018

ISSN (print): 1743-5889

ISSN (electronic): 1748-6963

Publisher: Future Medicine Ltd.

URL: https://doi.org/10.2217/nnm-2018-0064

DOI: 10.2217/nnm-2018-0064

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