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Nanoparticle transport pathways into tumors

Lookup NU author(s): Professor Moein MoghimiORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.

Publication metadata

Author(s): Moghimi SM, Simberg D

Publication type: Article

Publication status: Published

Journal: Journal of Nanoparticle Research

Year: 2018

Volume: 20

Issue: 6

Print publication date: 01/06/2018

Online publication date: 21/06/2018

Acceptance date: 11/06/2018

Date deposited: 22/06/2018

ISSN (print): 1388-0764

ISSN (electronic): 1572-896X

Publisher: Springer


DOI: 10.1007/s11051-018-4273-8


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