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Lookup NU author(s): Dr Simon Nichols
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© 2017 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd Objective: Cardiopulmonary exercise testing (CPET) is the ‘gold standard’ method of determining VO2peak. When CPET is unavailable, VO2peak may be estimated from treadmill or cycle ergometer workloads and expressed as estimated metabolic equivalents (METs). Cardiac rehabilitation (CR) programmes use estimated VO2peak (METs) to report changes in cardiorespiratory fitness (CRF). However, the accuracy of determining changes in VO2peak based on estimated functional capacity is not known. Methods: A total of 27 patients with coronary heart disease (88·9% male; age 59·5 ± 10·0 years, body mass index 29·6 ± 3·8 kg m−2) performed maximal CPET before and after an exercise-based CR intervention. VO2peak was directly determined using ventilatory gas exchange data and was also estimated using the American College of Sports Medicine (ACSM) leg cycling equation. Agreement between changes in directly determined VO2peak and estimated VO2peak was evaluated using Bland–Altman limits of agreement (LoA) and intraclass correlation coefficients. Results: Directly determined VO2peak did not increase following CR (0·5 ml kg−1 min−1 (2·7%); P = 0·332). Estimated VO2peak increased significantly (0·4 METs; 1·4 ml kg−1 min−1; 6·7%; P = 0·006). The mean bias for estimated VO2peak versus directly determined VO2peak was 0·7 ml kg−1 min−1 (LoA −4·7 to 5·9 mlkg−1 min−1). Aerobic efficiency (ΔVO2/ΔWR slope) was significantly associated with estimated VO2peak measurement error. Conclusion: Change in estimated VO2peak derived from the ACSM leg cycling equation is not an accurate surrogate for directly determined changes in VO2peak. Our findings show poor agreement between estimates of VO2peak and directly determined VO2peak. Applying estimates of VO2peak to determine CRF change may over-estimate the efficacy of CR and lead to a different interpretation of study findings.
Author(s): Nichols S, Gleadall-Siddall DO, Antony R, Clark AL, Cleland JGF, Carroll S, Ingle L
Publication type: Article
Publication status: Published
Journal: Clinical Physiology and Functional Imaging
Year: 2018
Volume: 38
Issue: 4
Pages: 681-688
Print publication date: 01/07/2018
Online publication date: 30/08/2017
Acceptance date: 14/07/2017
ISSN (print): 1475-0961
ISSN (electronic): 1475-097X
Publisher: John Wiley & Sons Ltd
URL: https://doi.org/10.1111/cpf.12468
DOI: 10.1111/cpf.12468
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