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The impact of single-cell RNA sequencing on understanding the functional organization of the immune system

Lookup NU author(s): Dr Peter Vegh, Professor Muzlifah Haniffa



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics technologies provide high-dimensional assessment of the transcriptional states of immune cells and have been successfully applied to discover new immune cell types, reveal haematopoietic lineages, identify gene modules dictating immune responses and investigate lymphocyte antigen receptor diversity. In this review, we discuss the impact and applications of single-cell RNA sequencing technologies in immunology.

Publication metadata

Author(s): Vegh P, Haniffa M

Publication type: Article

Publication status: Published

Journal: Briefings in Functional Genomics

Year: 2018

Volume: 17

Issue: 4

Pages: 265-272

Print publication date: 01/07/2018

Online publication date: 14/03/2018

Acceptance date: 14/03/2018

Date deposited: 25/06/2018

ISSN (print): 2041-2649

ISSN (electronic): 2041-2657

Publisher: Oxford University Press


DOI: 10.1093/bfgp/ely003


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Funder referenceFunder name
Wellcome Trust