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Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study

Lookup NU author(s): Dr Holly Bennett, Professor Carol Brayne, Professor Fiona MatthewsORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2018 The Author(s). Background: With declining rates of participation in epidemiological studies there is an important need to attempt to understand what factors might affect response. This study examines the pattern of response at different adult ages within a contemporary cross-sectional population-based cohort, the Cambridge Centre for Ageing and Neuroscience (Cam-CAN). Methods: Using logistic regression, we investigated associations between age, gender and Townsend deprivation level for both participants and non-participants. Weighted estimates of the odds ratios with confidence intervals for each demographic characteristic were calculated. Reasons given for refusal were grouped into three broad categories: 'active', 'passive' and illness preventing interview. Results: An association of age and participation was found, with individuals in middle age groups more likely to participate (age group 48-57 OR: 1.8, 95% CI: 1.5-2.2 and age group 58-67 OR: 2.1, 95% CI: 1.7-2.4). Overall, there was no difference in participation between men and women. An association with deprivation was found, with those living in the most deprived areas being the least willing to participate (fifth quintile OR: 0.6, 95% CI: 0.5-0.7). An interaction between age and gender was found whereby younger women and older men were more likely to agree to participate (p = 0.01). Conclusion: Our findings highlight some of the factors affecting recruitment into epidemiological studies in the UK and suggest that targeted age-specific recruitment strategies might be needed to increase participation rates in future cohort investigations.

Publication metadata

Author(s): Green E, Bennett H, Brayne C, Tyler LK, Bullmore ET, Calder AC, Cusack R, Dalgleish T, Duncan J, Henson RN, Marslen-Wilson WD, Rowe JB, Shafto MA, Campbell K, Cheung T, Davis S, Geerligs L, Kievit R, McCarrey A, Mustafa A, Price D, Samu D, Taylor JR, Treder M, Tsvetanov K, Van Belle J, Williams N, Bates L, Emery T, Erzinclioglu S, Gadie A, Gerbase S, Georgieva S, Hanley C, Parkin B, Troy D, Auer T, Correia M, Gao L, Henriques R, Allen J, Amery G, Amunts L, Barcroft A, Castle A, Dias C, Dowrick J, Fair M, Fisher H, Goulding A, Grewal A, Hale G, Hilton A, Johnson F, Johnston P, Kavanagh-Williamson T, Kwasniewska M, McMinn A, Norman K, Penrose J, Roby F, Rowland D, Sargeant J, Squire M, Stevens B, Stoddart A, Stone C, Thompson T, Yazlik O, Barnes D, Dixon M, Hillman J, Mitchell J, Villis L, Matthews FE

Publication type: Article

Publication status: Published

Journal: BMC Public Health

Year: 2018

Volume: 18

Issue: 1

Online publication date: 19/06/2018

Acceptance date: 03/06/2018

Date deposited: 03/07/2018

ISSN (electronic): 1471-2458

Publisher: BioMed Central Ltd.


DOI: 10.1186/s12889-018-5663-7


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