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Reported analgesic and anaesthetic administration to non-human primates undergoing experimental surgical procedure: 2010-2015

Lookup NU author(s): Henri Bertrand, Emeritus Professor Paul Flecknell

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Abstract

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background: The use of non-human primates (NHPs) in research remains a major societal concern with public expectations that appropriate anaesthetics and analgesics are used to minimize any pain or distress caused to animals undergoing invasive procedures. A literature review was conducted to examine the reporting of anaesthesia and analgesia methods used in non-human primates undergoing surgical procedures, with recovery from anaesthesia. Methods: A total of 397 papers from peer-review journals published between 2010 and 2015 were examined. Results: Only 25.9% of papers reported the analgesic regimen used, with carprofen and buprenorphine the 2 most widely used agents. Reporting of the anaesthetic regimens was included in 49.9% of papers. Ketamine and isoflurane were the most frequently used anaesthetic agents. Conclusions: Anaesthetic and analgesic regimens administered to NHPs remain poorly reported. This lack of detailed descriptions of protocols does little to reassure the public or regulatory authorities that appropriate high standards of perioperative care are employed.


Publication metadata

Author(s): Bertrand HGMJ, Sandersen C, Flecknell PA

Publication type: Article

Publication status: Published

Journal: Journal of Medical Primatology

Year: 2018

Volume: 47

Issue: 4

Pages: 217-225

Print publication date: 01/08/2018

Online publication date: 19/04/2018

Acceptance date: 02/03/2018

ISSN (print): 0047-2565

ISSN (electronic): 1600-0684

Publisher: Wiley-Blackwell

URL: https://doi.org/10.1111/jmp.12346

DOI: 10.1111/jmp.12346


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