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Planar cell polarity in organ formation

Lookup NU author(s): Professor Deborah HendersonORCiD


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© 2018 Elsevier Ltd The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.

Publication metadata

Author(s): Henderson DJ, Long DA, Dean CH

Publication type: Review

Publication status: Published

Journal: Current Opinion in Cell Biology

Year: 2018

Volume: 55

Pages: 96-103

Print publication date: 01/12/2018

Online publication date: 14/07/2018

Acceptance date: 02/04/2018

ISSN (print): 0955-0674

ISSN (electronic): 1879-0410

Publisher: Elsevier Ltd


DOI: 10.1016/