Lookup NU author(s): Professor Deborah Henderson
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© 2018 Elsevier Ltd The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.
Author(s): Henderson DJ, Long DA, Dean CH
Publication type: Review
Publication status: Published
Journal: Current Opinion in Cell Biology
Print publication date: 01/12/2018
Online publication date: 14/07/2018
Acceptance date: 02/04/2018
ISSN (print): 0955-0674
ISSN (electronic): 1879-0410
Publisher: Elsevier Ltd