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Rapid retrograde regulation of transmitter release at the NMJ

Lookup NU author(s): Emeritus Professor Clarke Slater


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© 2018 Elsevier Ltd Numerous regulatory processes act to ensure effective signal transmission at neuromuscular junctions (NMJs). In the disease myasthenia gravis (MG), the muscle response to transmitter is impaired but transmitter release from the nerve is enhanced. Recently evidence has emerged of a rapid (seconds to minutes) form of retrograde regulation of release, known as ‘homeostatic plasticity’ (HP). At mouse and Drosophila NMJs HP can be triggered by mimicking MG by blocking some of the postsynaptic transmitter receptors. Whether HP accounts for the increased release in MG is unclear, as is the identity of any natural trigger of HP, the retrograde signal, or the target of the signal. Better knowledge of HP might suggest better ways of treating some forms of NMJ disorder.

Publication metadata

Author(s): Ribchester RR, Slater CR

Publication type: Review

Publication status: Published

Journal: Current Opinion in Physiology

Year: 2018

Volume: 4

Pages: 82-87

Print publication date: 01/08/2018

Online publication date: 03/07/2018

Acceptance date: 02/04/2018

ISSN (print): 2468-8681

ISSN (electronic): 2468-8673

Publisher: Elsevier Ltd


DOI: 10.1016/j.cophys.2018.06.007