ePrints

Transplantation of kidneys from DCD and DBD donors who died after ligature asphyxiation: The UK experience

Lookup NU author(s): Chris Watson

Downloads

• Published version [.pdf]

Licence

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

© 2018 The American Society of Transplantation and the American Society of Transplant Surgeons. There is uncertainty about whether hypoxic injury accompanying donor death from ligature asphyxiation influences renal transplant outcomes, particularly for recipients of kidneys donated after circulatory death (DCD). The UK Registry analysis was undertaken to determine transplant outcomes in recipients of kidneys from donors who died following ligature asphyxiation. From 2003 to 2016, 2.7% (n = 521) of potential organ donors died following ligature asphyxiation (mostly suicide by hanging). Of these, 409 (78.5%) donated kidneys for transplantation (46.9% donation after brain death [DBD] and 53.1% DCD donors) resulting in 650 kidney transplants. Compared to other deceased donors, those dying from ligature asphyxiation were younger, more often male, and had less hypertension. Unadjusted patient and graft survival were superior for recipients of both DBD and DCD kidneys from donors dying after ligature asphyxiation, although after adjustment for donor/recipient variables, transplant outcomes were similar. A case-control matched analysis confirmed transplant outcomes for those who received kidneys from donors dying after ligature asphyxiation were similar to controls. Although caution is required in interpreting these findings because of potential selection bias, kidneys from donors dying of ligature asphyxiation suffer an additional warm ischemic insult that does not apparently adversely influence transplant outcomes, even for kidneys from DCD donors.

Publication metadata

Author(s): Trotter PB, Jochmans I, Hulme W, Robb M, Watson C, Neuberger J, Andrew Bradley J

Publication type: Article

Publication status: Published

Journal: American Journal of Transplantation

Year: 2018

Volume: 18

Issue: 11

Pages: 2739-2751

Print publication date: 01/11/2018

Online publication date: 27/06/2018

Acceptance date: 18/06/2018

Date deposited: 13/08/2018

ISSN (print): 1600-6135

ISSN (electronic): 1600-6143

Publisher: Wiley-Blackwell

URL: https://doi.org/10.1111/ajt.14989

DOI: 10.1111/ajt.14989

Altmetrics

Share