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Pulsatile release from self-oscillating chitosan macrogels

Lookup NU author(s): Dr Anna Isakova, Dr Katarina Novakovic


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Pulsatile drug delivery is a cornerstone issue in personalised pharmacotherapy, which, as believed, can be solved by coupling of the smart materials, capable to respond to the external stimuli, to oscillatory chemical reactions. For example, oscillations in pH or redox properties within one single architecture can serve as the stimuli and induce swelling and collapsing of a polymeric hydrogel, resulting in a pulsed drug release. As a proof-of-concept, here we demonstrate a pulsatile release of sodium fluorescein drug from chitosan-based macrogels which employ palladium-catalysed oxidative carbonylation (PCOC) reaction as a driving force of the pH oscillations, sustained within the macrogel. Chitosan-imine supported palladium chloride was distributed uniformly within the macrogel and served as a non-leaching catalyst. In methanol:water solvent system fluorescein was released in pulses (135-280 min), corresponding to the stepwise decrease in pH, associated with the oscillatory process within the macrogel. Although this system is far from ready for in vivo applications, this is the first report of pulsatile release from a macrogel coupled to an oscillatory chemical reaction, and it opens new directions towards smart material architectures.

Publication metadata

Author(s): Isakova A, Novakovic K

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: World Polymer Congres (MACRO2018)

Year of Conference: 2018

Online publication date: 01/07/2018

Acceptance date: 23/02/2018