Toggle Main Menu Toggle Search

Open Access padlockePrints

A Head Mounted Device Stimulator for Optogenetic Retinal Prosthesis

Lookup NU author(s): Dr Walid Al-Atabany, Professor Evelyne Sernagor, Professor Patrick Degenaar

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

It typically takes two decades to move from a major biological discovery to medical practice. Optogenetics is following that pathway and now in the process of being used in clinical trials for optogenetic retinal prosthetics. Initially, efforts will centre on the molecular biology of the photosensitization. However, as the trials move towards practical systems, intensifier headsets are required to provide optical stimulus far exceeding that of consumer augmented reality systems. We demonstrate that in keeping with regulatory guidance, the headset displays need to limit their luminance to 90,332 cd/m2. We demonstrate an optical system with 5.75% efficiency which allows for 0.16 mW/mm2 irradiance on the retina within the regulatory guidance, but which is capable of an average peak power of 1.35 mW/mm2. As this is lower than the commonly accepted threshold for channelrhodopsin-2, we demonstrate efficacy through an optical model of an eye onto a biological retina. Finally, we demonstrate a fully functional 8100-pixel headset system including software/hardware which can operate on a standard consumer battery for periods exceeding a 24hour recharge cycle.


Publication metadata

Author(s): Soltan A, Barrett J, Maaskant P, Chaudet L, Al-Atabany W, Akhter M, Armstrong N, Corbett B, Neil M, Sernagor E, Degenaar P

Publication type: Article

Publication status: Published

Journal: Journal of Neural Engineering

Year: 2018

Volume: 15

Issue: 6

Online publication date: 29/09/2018

Acceptance date: 29/08/2018

Date deposited: 19/09/2018

ISSN (print): 1741-2560

ISSN (electronic): 1741-2552

Publisher: Institute of Physics Publishing Ltd.

URL: https://doi.org/10.1088/1741-2552/aadd55

DOI: 10.1088/1741-2552/aadd55


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share