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Lookup NU author(s): Dr Mabel LieORCiD,
Professor Christopher HardingORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Introduction and hypothesisThe aim of this study was to identify modifiable factors to improve recruitment in a urology clinical trial of women with recurrent urinary tract infection (rUTI). An embedded qualitative study was conducted with patients and recruiting clinicians in the first eight months of the trial. We present a matrix of factors influencing how patients make decisions about trial participation. MethodsThis was a qualitative study using telephone interviews. At the time they were approached about the trial women were asked to complete an expression of interest form if they wished to be contacted about an interview. Data were analysed thematically. NVivo 10 software  was used as a management tool. ResultsThirty patients and 11 clinicians were interviewed. Influences on patient participation included: the impact of rUTI on quality of life; understanding of antibiotic resistance and previous experiences with antibiotics which may be positive or negative. Very few women who declined the trial agreed to be interviewed. However, some of those who participated in the trial had reservations about it. These included the perceived risk of trying a new treatment, the length of the trial and the burden of participating. One person interviewed left the trial because of repeated infections and difficulties getting GP appointments.ConclusionsA combination of factors worked to influence women to decide to participate, to remain in, or to leave the trial. A better understanding of how these factors interact and work can assist in the recruitment and retention of individual trial participants.
Author(s): Lie MLS, Lecouturier J, Harding C
Publication type: Article
Publication status: Published
Journal: International Urogynecology Journal
Print publication date: 01/01/2019
Online publication date: 17/10/2018
Acceptance date: 18/09/2018
Date deposited: 19/09/2018
ISSN (print): 0937-3462
ISSN (electronic): 1433-3023
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