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Should I stay or should I go? A qualitative study exploring participation in a urology clinical trial​

Lookup NU author(s): Dr Mabel LieORCiD, Jan Lecouturier, Professor Christopher HardingORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Introduction and hypothesisThe aim of this study was to identify modifiable factors to improve recruitment in a urology clinical trial of women with recurrent urinary tract infection (rUTI). An embedded qualitative study was conducted with patients and recruiting clinicians in the first eight months of the trial. We present a matrix of factors influencing how patients make decisions about trial participation. MethodsThis was a qualitative study using telephone interviews. At the time they were approached about the trial women were asked to complete an expression of interest form if they wished to be contacted about an interview. Data were analysed thematically. NVivo 10 software [1] was used as a management tool. ResultsThirty patients and 11 clinicians were interviewed. Influences on patient participation included: the impact of rUTI on quality of life; understanding of antibiotic resistance and previous experiences with antibiotics which may be positive or negative. Very few women who declined the trial agreed to be interviewed. However, some of those who participated in the trial had reservations about it. These included the perceived risk of trying a new treatment, the length of the trial and the burden of participating. One person interviewed left the trial because of repeated infections and difficulties getting GP appointments.ConclusionsA combination of factors worked to influence women to decide to participate, to remain in, or to leave the trial. A better understanding of how these factors interact and work can assist in the recruitment and retention of individual trial participants.

Publication metadata

Author(s): Lie MLS, Lecouturier J, Harding C

Publication type: Article

Publication status: Published

Journal: International Urogynecology Journal

Year: 2019

Volume: 30

Issue: 1

Pages: 9-16

Print publication date: 01/01/2019

Online publication date: 17/10/2018

Acceptance date: 18/09/2018

Date deposited: 19/09/2018

ISSN (print): 0937-3462

ISSN (electronic): 1433-3023

Publisher: Springer

URL: https://doi.org/10.1007/s00192-018-3784-2

DOI: 10.1007/s00192-018-3784-2

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