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Laryngeal dysplasia and narrow band imaging: Secondary analysis of published data supports the role in patient follow-up

Lookup NU author(s): Professor Vinidh Paleri, Dr Holly FisherORCiD, Dr Deborah Stocken


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© 2018 John Wiley & Sons Ltd. Background: Clinicians have recognised the role of narrow band imaging (NBI) in the management of head and neck cancer in several studies. However, a recent systematic review was unable to pool the data on diagnostic efficacy in this setting owing to the heterogeneity in the published data. Methods: Secondary analysis of data, utilising Bayes' theorem, from meta-analyses and randomised trials. Results: In patients with a histological diagnosis of mild dysplasia who show no abnormalities on NBI, the post-test probability of malignancy is estimated to be 2.3%, compared to 10.3% with conventional white light imaging (WLI). For severe dysplasia, similar post-test probabilities after NBI and WLI are estimated to be 8.0% and 29.7%, respectively. Post-test probabilities in this setting indicate the chance of missing malignancy following a negative NBI or WLI in patients who undergo no further intervention. This study also provides a nomogram designed for use in this setting. Conclusions: This study identifies the evidence base for use of NBI in the follow-up for laryngeal dysplasia.

Publication metadata

Author(s): Paleri V, Sawant R, Mehanna H, Ainsworth H, Stocken D

Publication type: Article

Publication status: Published

Journal: Clinical Otolaryngology

Year: 2018

Volume: 43

Issue: 6

Pages: 1439-1442

Print publication date: 01/12/2018

Online publication date: 04/07/2018

Acceptance date: 17/06/2018

ISSN (print): 1749-4478

ISSN (electronic): 1749-4486

Publisher: John Wiley & Sons Ltd


DOI: 10.1111/coa.13182


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