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Lookup NU author(s): Professor Vinidh Paleri, Dr Holly FisherORCiD, Dr Deborah Stocken
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© 2018 John Wiley & Sons Ltd. Background: Clinicians have recognised the role of narrow band imaging (NBI) in the management of head and neck cancer in several studies. However, a recent systematic review was unable to pool the data on diagnostic efficacy in this setting owing to the heterogeneity in the published data. Methods: Secondary analysis of data, utilising Bayes' theorem, from meta-analyses and randomised trials. Results: In patients with a histological diagnosis of mild dysplasia who show no abnormalities on NBI, the post-test probability of malignancy is estimated to be 2.3%, compared to 10.3% with conventional white light imaging (WLI). For severe dysplasia, similar post-test probabilities after NBI and WLI are estimated to be 8.0% and 29.7%, respectively. Post-test probabilities in this setting indicate the chance of missing malignancy following a negative NBI or WLI in patients who undergo no further intervention. This study also provides a nomogram designed for use in this setting. Conclusions: This study identifies the evidence base for use of NBI in the follow-up for laryngeal dysplasia.
Author(s): Paleri V, Sawant R, Mehanna H, Ainsworth H, Stocken D
Publication type: Article
Publication status: Published
Journal: Clinical Otolaryngology
Year: 2018
Volume: 43
Issue: 6
Pages: 1439-1442
Print publication date: 01/12/2018
Online publication date: 04/07/2018
Acceptance date: 17/06/2018
ISSN (print): 1749-4478
ISSN (electronic): 1749-4486
Publisher: John Wiley & Sons Ltd
URL: https://doi.org/10.1111/coa.13182
DOI: 10.1111/coa.13182
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