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Liquid biopsy for liver diseases

Lookup NU author(s): Professor Jelena Mann, Professor Helen ReevesORCiD


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© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ. With the growing number of novel therapeutic approaches for liver diseases, significant research efforts have been devoted to the development of liquid biopsy tools for precision medicine. This can be defined as non-invasive reliable biomarkers that can supplement and eventually replace the invasive liver biopsy for diagnosis, disease stratification and monitoring of response to therapeutic interventions. Similarly, detection of liver cancer at an earlier stage of the disease, potentially susceptible to curative resection, can be critical to improve patient survival. Circulating extracellular vesicles, nucleic acids (DNA and RNA) and tumour cells have emerged as attractive liquid biopsy candidates because they fulfil many of the key characteristics of an ideal biomarker. In this review, we summarise the currently available information regarding these promising and potential transformative tools, as well as the issues still needed to be addressed for adopting various liquid biopsy approaches into clinical practice. These studies may pave the way to the development of a new generation of reliable, mechanism-based disease biomarkers.

Publication metadata

Author(s): Mann J, Reeves HL, Feldstein AE

Publication type: Article

Publication status: Published

Journal: Gut

Year: 2018

Volume: 67

Issue: 12

Pages: 2204-2212

Print publication date: 01/12/2018

Online publication date: 03/09/2018

Acceptance date: 25/07/2018

ISSN (print): 0017-5749

ISSN (electronic): 1468-3288

Publisher: BMJ Group


DOI: 10.1136/gutjnl-2017-315846


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