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Recent advances in understanding the role of FOXO3 [version 1; referees: 4 approved]

Lookup NU author(s): Dr Renae StefanettiORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2018 Stefanetti RJ et al. The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.

Publication metadata

Author(s): Stefanetti RJ, Voisin S, Russell A, Lamon S

Publication type: Review

Publication status: Published

Journal: F1000Research

Year: 2018

Volume: 7

Online publication date: 31/08/2018

Acceptance date: 02/04/2018

ISSN (print): 2046-1402

ISSN (electronic): 1759-796X

Publisher: F1000 Research Ltd


DOI: 10.12688/f1000research.15258.1