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Using penalized regression to predict phenotype from SNP data

Lookup NU author(s): Dr Svetlana Cherlin, Dr Richard Howey, Professor Heather Cordell

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2018 The Author(s). Background: In a typical genome-enabled prediction problem there are many more predictor variables than response variables. This prohibits the application of multiple linear regression, because the unique ordinary least squares estimators of the regression coefficients are not defined. To overcome this problem, penalized regression methods have been proposed, aiming at shrinking the coefficients toward zero. Methods: We explore prediction of phenotype from single nucleotide polymorphism (SNP) data in the GAW20 data set using a penalized regression approach (LASSO [least absolute shrinkage and selection operator] regression). We use 10-fold cross-validation to assess predictive performance and 10-fold nested cross-validation to specify a penalty parameter. Results: By analyzing approximately 600,000 SNPs we find that, when the sample size comprises a few hundred individuals, SNP effects are heavily penalized, resulting in a poor predictive performance. Increasing the sample size to a few thousand individuals results in a much smaller penalization of the true effects, thus greatly improving the prediction. Conclusions: LASSO regression results in a heavy shrinkage of the regression coefficients, and also requires large sample sizes (several thousand individuals) to achieve good prediction.


Publication metadata

Author(s): Cherlin S, Howey RAJ, Cordell HJ

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Genetic Analysis Workshop 20

Year of Conference: 2018

Online publication date: 17/09/2018

Acceptance date: 04/03/2017

Date deposited: 08/10/2018

Publisher: BioMed Central Ltd.

URL: https://doi.org/10.1186/s12919-018-0149-2

DOI: 10.1186/s12919-018-0149-2

Series Title: BMC Proceedings


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