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42/Aβ40 and Aβ42/Aβ38 Ratios Are Associated with Measures of Gait Variability and Activities of Daily Living in Mild Alzheimer's Disease: A Pilot Study

Lookup NU author(s): Dr Brook Galna, Professor Alan ThomasORCiD, Professor Lynn RochesterORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© 2018-IOS Press and the authors. All rights reserved. Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer's disease (AD) remains to be clarified. In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF. CSF Aβ42/Aβ40 and Aβ42/Aβ38 correlated positively with measures of variability (step time and step length) in the clinic-based assessments. This was driven by a negative relationship between gait variability and Aβ40 and Aβ38 but not Aβ42.The amyloid ratios and gait variability measures were also associated with more severe functional impairment. We interpret these data as an indication that increasing amyloid production (i.e., increasing Aβ40 and Aβ38) is associated with diminishing cognitive-motor control of gait. These preliminary results suggest that the two amyloid ratios may be a marker of the earliest disturbances in the interplay between cognitive and motor control which characterize dementia.

Publication metadata

Author(s): Koychev I, Galna B, Zetterberg H, Lawson J, Zamboni G, Ridha BH, Rowe JB, Thomas A, Howard R, Malhotra P, Ritchie C, Lovestone S, Rochester L

Publication type: Article

Publication status: Published

Journal: Journal of Alzheimer's Disease

Year: 2018

Volume: 65

Issue: 4

Pages: 1377-1383

Online publication date: 25/09/2018

Acceptance date: 01/08/2018

Date deposited: 15/10/2018

ISSN (print): 1387-2877

ISSN (electronic): 1875-8908

Publisher: IOS Press


DOI: 10.3233/JAD-180622


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Funder referenceFunder name
Dementias Platform UK
Medical Research Council
National Institute of Health Research
Newcastle Hospitals NHS Foundation Trust
NIHR Biomedical Research Centre
Oxford University Hospitals NHS Foundation Trust
University of Cambridge
University College London Hospitals