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Outcome of cell suspension allografts in a patient with Huntington’s disease

Lookup NU author(s): Professor Nicola PaveseORCiD

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Abstract

For patients with incurable neurodegenerative disorders such as Huntington’s (HD) and Parkinson’s disease, cell transplantation has been explored as a potential treatment option. Here we present the first clinico-pathological study of a patient with HD in receipt of cell-suspension striatal allografts who took part in the NEST-UK multi-centre clinical transplantation trial. Using various immunohistochemical techniques, we found a discrepancy in the survival of grafted projection neurons with respect to grafted interneurons as well as a major ongoing inflammatory and immune responses to the grafted tissue with evidence of mutant huntingtin aggregates within the transplant area. Our results indicate that grafts can survive more than a decade post-transplantation but show compromised survival with inflammation and mutant protein being seen within the transplant site.

Publication metadata

Author(s): Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, Tremblay ME, Gould P, Rosser AE, Dunnett SB, Piccini P, Barker RA, Cicchetti F

Publication type: Article

Publication status: Published

Journal: Annals of Neurology

Year: 2018

Volume: 84

Issue: 6

Pages: 950-956

Print publication date: 01/12/2018

Online publication date: 04/10/2018

Acceptance date: 27/09/2018

Date deposited: 22/10/2018

ISSN (print): 0364-5134

ISSN (electronic): 1531-8249

Publisher: John Wiley & Sons, Inc.

URL: https://doi.org/10.1002/ana.25354

DOI: 10.1002/ana.25354

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