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Lookup NU author(s): Professor Simon Thomas
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AIM: To examine temporal trends in accesses to the UK's National Poison Information Service's TOXBASE database in Britain. METHODS: Generalized additive models were used to examine trends in daily numbers of accesses to TOXBASE from British emergency departments between January 2008 and December 2015. Day-of-the-week, seasonality and long-term trends were analysed at national and regional levels (Wales, Scotland and the nine English Government Office Regions). RESULTS: The long-term trend in daily accesses increases from 2.8 (95% confidence interval (CI): 2.6-3.0) per user on 1 January 2008 to 4.6 (95% CI: 4.3-4.9) on 31 December 2015, with small but significant differences in population-corrected accesses by region ( p < 0.001). There are statistically significant seasonal and day of the week patterns ( p < 0.001) across all regions. Accesses are 18% (95% CI: 14-22%) higher in summer than in January and at the weekend compared to weekdays in all regions; there is a 7.5% (95% CI: 6.1-8.9%) increase between Friday and Sunday. CONCLUSIONS: There are consistent in-year patterns in access to TOXBASE indicating potential seasonal patterns in poisonings in Britain, with location-dependent rates of usage. This novel descriptive work lays the basis for future work on the interaction of TOXBASE use with emergency admission of patients into hospital.
Author(s): Pyper K, Eddleston M, Bateman DN, Lupton D, Bradberry S, Sandilands E, Thomas S, Thompson JP, Robertson C
Publication type: Article
Publication status: Published
Journal: Human & Experimental Toxicology
Print publication date: 01/11/2018
Online publication date: 20/02/2018
Acceptance date: 02/04/2016
ISSN (print): 0960-3271
ISSN (electronic): 1477-0903
Publisher: Sage Publications Ltd
PubMed id: 29460637
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