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Geographical analysis of thyroid cancer in young people from northern England: Evidence for a sustained excess in females in Cumbria

Lookup NU author(s): Dr Brooke Magnanti, Dr Tevfik Dorak, Professor Louise Parker, Emeritus Professor Alan Craft, Dr Peter James, Dr Richard McNallyORCiD


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A previous study found a thyroid cancer excess in Cumbria following the Chernobyl explosion, but did not analyse sex-specific effects. This study examines sex differences in the incidence of thyroid cancer. Ninety-five primary thyroid carcinomas (69 females, 26 males) diagnosed in those aged 0-24 during 1968-2005 were identified from the Northern Region Young Persons' Malignant Disease Registry. Age-standardised incidence rates (ASRs), rate ratios (RRs) and 95% confidence intervals (CIs) were calculated. For males, the ASR was 0.6 per million person-years during the pre-Chernobyl period (1968-1986), and was 1.8 per million person-years during the post-Chernobyl period (1987-2005). For females, the ASR was 2.4 pre-Chernobyl and was 3.9 post-Chernobyl. The previously noted excess in Cumbria was entirely confined to females (Cumbrian females: RR for post-Chernobyl compared with pre-Chernobyl=10.8; 95% CI: 1.4-85.3). These findings may be consistent with sex-specific differences in susceptibility to an environmental exposure, such as fallout from the Chernobyl nuclear accident.

Publication metadata

Author(s): Magnanti BL, Dorak MT, Parker L, Craft AW, James PW, McNally RJQ

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 2009

Volume: 45

Issue: 9

Pages: 1624-1629

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852

Publisher: Pergamon


DOI: 10.1016/j.ejca.2008.12.024

PubMed id: 19179067


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