ePrints

Geographical analysis of thyroid cancer in young people from northern England: Evidence for a sustained excess in females in Cumbria

Lookup NU author(s): Dr Brooke Magnanti, Dr Tevfik Dorak, Professor Louise Parker, Emeritus Professor Alan Craft, Dr Peter James, Dr Richard McNallyORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

A previous study found a thyroid cancer excess in Cumbria following the Chernobyl explosion, but did not analyse sex-specific effects. This study examines sex differences in the incidence of thyroid cancer. Ninety-five primary thyroid carcinomas (69 females, 26 males) diagnosed in those aged 0-24 during 1968-2005 were identified from the Northern Region Young Persons' Malignant Disease Registry. Age-standardised incidence rates (ASRs), rate ratios (RRs) and 95% confidence intervals (CIs) were calculated. For males, the ASR was 0.6 per million person-years during the pre-Chernobyl period (1968-1986), and was 1.8 per million person-years during the post-Chernobyl period (1987-2005). For females, the ASR was 2.4 pre-Chernobyl and was 3.9 post-Chernobyl. The previously noted excess in Cumbria was entirely confined to females (Cumbrian females: RR for post-Chernobyl compared with pre-Chernobyl=10.8; 95% CI: 1.4-85.3). These findings may be consistent with sex-specific differences in susceptibility to an environmental exposure, such as fallout from the Chernobyl nuclear accident.

Publication metadata

Author(s): Magnanti BL, Dorak MT, Parker L, Craft AW, James PW, McNally RJQ

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 2009

Volume: 45

Issue: 9

Pages: 1624-1629

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.ejca.2008.12.024

DOI: 10.1016/j.ejca.2008.12.024

PubMed id: 19179067

Altmetrics

Share