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Advanced pretreatment stage in oesophageal cancer not associated with poor outcomes

Lookup NU author(s): Professor Alexander PhillipsORCiD, Arul Immanuel, Nick Hayes, Professor Michael Griffin


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Background Following a diagnosis of oesophageal cancer UICC TNM staging guides treatment and informs prognosis. There is recognised variance between clinical staging (cTNM) and post-operative pathological staging (pTNM). T3N3 oesophageal cancers have a 5-year survival of less than 25% in most studies; given the morbidity associated with radical treatment these cancers may not be considered curable. Methods A database of patients treated in a high volume UK tertiary referral centre was interrogated for all cT3N3M0 patients. Demographics, pathological stage and outcomes were recorded. Results From 2011 to 2016 34 patients met the inclusion criteria of cT3N3M0 oesophageal cancer. 11 patients had squamous cell carcinoma, the remainder adenocarcinoma. Median age was 65. Predicted overall survival at two years was 71% with a median overall survival of 54 months. 29 patients had neoadjuvant chemotherapy. All patients had an R0 resection. In 15% of patients clinical stage equated to pathological stage, 9% were ’understaged’, 76% had a better prognostic pathological stage. pStage Tx/0 N0 T1/2 N0 T3/4 N0 T1 N+ T2 N+ T3 N+ T4 N+ Number 4 7 2 2 1 16 2 pStage Tx/0 N0 T1/2 N0 T3/4 N0 T1 N+ T2 N+ T3 N+ T4 N+ Number 4 7 2 2 1 16 2 pStage Tx/0 N0 T1/2 N0 T3/4 N0 T1 N+ T2 N+ T3 N+ T4 N+ Number 4 7 2 2 1 16 2 pStage Tx/0 N0 T1/2 N0 T3/4 N0 T1 N+ T2 N+ T3 N+ T4 N+ Number 4 7 2 2 1 16 2 Conclusion Staging is considered important to allow treatment to be tailored to the individual patient. Identifying an unfavourable clinical stage may prevent inappropriate treatment, but may disadvantage patients who are erroneously ‘overstaged’. This study highlights variance between pre-treatment clinical staging and post-operative pathological staging. Care should be taken when making treatment decisions and counselling patients who have a poor prognostic clinical stage

Publication metadata

Author(s): Newton N, Phillips AW, Jaretzke H, Immanual A, Hayes N, Griffin SM

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 16th World Congress of the International Society for Diseases of the Esophagus

Year of Conference: 2018

Pages: 143-143

Print publication date: 01/09/2018

Online publication date: 14/09/2018

Acceptance date: 01/05/2018

ISSN: 1442-2050

Publisher: Oxford University Press


DOI: 10.1093/dote/doy089.PS02.081

Series Title: Diseases of the Esophagus