Toggle Main Menu Toggle Search

Open Access padlockePrints

Effects of dietary interventions on DNA methylation in adult humans: Systematic review and meta-analysis

Lookup NU author(s): Khalil ElGendy, Dr Fiona MalcomsonORCiD, David Bradburn, Professor John Mathers

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

© 2018 The Authors. DNA methylation is a key component of the epigenetic machinery that is responsible for regulating gene expression and, therefore, cell function. Patterns of DNA methylation change during development and ageing, differ between cell types, are altered in multiple diseases and can be modulated by dietary factors. However, evidence about the effects of dietary factors on DNA methylation patterns in humans is fragmentary. This study was initiated to collate evidence for causal links between dietary factors and changes in DNA methylation patterns. We carried out a systematic review of dietary intervention studies in adult humans using Medline, EMBASE and Scopus. Out of 22 149 screened titles, sixty intervention studies were included, of which 65% were randomised (n 39). Most studies (53%) reported data from blood analyses, whereas 27% studied DNA methylation in colorectal mucosal biopsies. Folic acid was the most common intervention agent (33%). There was great heterogeneity in the methods used for assessing DNA methylation and in the genomic loci investigated. Meta-analysis of the effect of folic acid on global DNA methylation revealed strong evidence that supplementation caused hypermethylation in colorectal mucosa (P=0·009). Meta-regression analysis showed that the dose of supplementary folic acid was the only identified factor (P<0·001) showing a positive relationship. In summary, there is limited evidence from intervention studies of effects of dietary factors, other than folic acid, on DNA methylation patterns in humans. In addition, the application of multiple different assays and investigations of different genomic loci makes it difficult to compare, or to combine, data across studies.


Publication metadata

Author(s): Elgendy K, Malcomson FC, Lara JG, Bradburn DM, Mathers JC

Publication type: Review

Publication status: Published

Journal: British Journal of Nutrition

Year: 2018

Volume: 120

Issue: 9

Pages: 961-976

Print publication date: 14/11/2018

Online publication date: 24/10/2018

Acceptance date: 20/07/2018

ISSN (print): 0007-1145

ISSN (electronic): 1475-2662

Publisher: Cambridge University Press

URL: https://doi.org/10.1017/S000711451800243X

DOI: 10.1017/S000711451800243X

PubMed id: 30355391


Share