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Lookup NU author(s): Dr Aikaterini GatsiouORCiD, Professor Konstantinos StellosORCiD
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Lippincott Williams & Wilkins, 2018.
For re-use rights please refer to the publisher's terms and conditions.
Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit the gigantic scientific breakthroughs of this century. This urges the cardiovascular research field to explore novel concepts with promising prognostic and therapeutic potential. This review attempts to introduce the newly emerging field of epitranscriptome (or else known as RNA epigenetics) to cardiovascular researchers and clinicians summarizing its applications on health and disease. The traditionally perceived, intermediate carrier of genetic information or as contemporary revised as, occasionally, even the final product of gene expression, RNA, is dynamically subjected to >140 different kinds of chemical modifications determining its fate, which may profoundly impact the cellular responses and thus both health and disease course. Which are the most prevalent types of these RNA modifications, how are they catalyzed, how are they regulated, which role may they play in health and disease, and which are the implications for the cardiovascular medicine are few important questions that are discussed in the present review.
Author(s): Gatsiou A, Stellos K
Publication type: Article
Publication status: Published
Journal: Circulation: Genomic and Precision Medicine
Year: 2018
Volume: 11
Issue: 9
Pages: e001927
Online publication date: 17/09/2018
Acceptance date: 02/04/2018
Date deposited: 15/02/2021
ISSN (print): 1942-325X
ISSN (electronic): 2574-8300
Publisher: Lippincott Williams & Wilkins
URL: https://doi.org/10.1161/CIRCGEN.118.001927
DOI: 10.1161/CIRCGEN.118.001927
PubMed id: 30354331
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