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Fatty liver disease and hepatocellular carcinoma: The pathologist’s view

Lookup NU author(s): Dr Dina Tiniakos, Joao Pais Maurício-Muir, Professor Helen ReevesORCiD


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© Springer Nature Switzerland AG 2018. Chronic alcohol misuse and progressed nonalcoholic fatty liver disease (NAFLD) due to the metabolic syndrome and resulting to nonalcoholic steatohepatitis (NASH) are prime causes of hepatocellular carcinoma (HCC) in Western industrialized countries. The incidence of HCC in NASH-cirrhosis is lower than that of HCC occuring in HCV-related or alcoholic cirrhosis. Up to 20% of cases of alcohol-associated HCC may develop in pre-cirrhotic liver while HCC is also increasingly recognised in pre-cirrhotic NASH raising questions on appropriate surveillance measures for these patient populations. The recently described steatohepatitic subtype of HCC presents with higher frequency in NAFLD compared to alcoholic liver disease (ALD) patients. This review will mainly focus on histopathology and summarize current data on the epidemiology, pathogenesis, diagnosis and management of NAFLD- and ALD-related HCC.

Publication metadata

Author(s): Tiniakos DG, Mauricio J, Reeves HL

Publication type: Book Chapter

Publication status: Published

Book Title: Alcohol and Cancer

Year: 2018

Volume: 1032

Pages: 55-69

Online publication date: 26/10/2018

Acceptance date: 02/04/2018

Series Title: Advances in Experimental Medicine and Biology

Publisher: Springer New York LLC


DOI: 10.1007/978-3-319-98788-0_4

PubMed id: 30362090

Library holdings: Search Newcastle University Library for this item

ISBN: 978319987873