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Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

Lookup NU author(s): Dr Arian Laurence


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© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal lamina propria, particularly in Crohn’s disease. CD161+ Treg cells had an all-trans retinoic acid (ATRA)-regulated gene signature, and CD161 expression on Treg cells was induced by ATRA, which directly regulated the CD161 gene. CD161 was co-stimulatory, and ligation with the T cell antigen receptor induced cytokines that accelerated the wound healing of intestinal epithelial cells. We identified a transcription-factor network, including BACH2, RORγt, FOSL2, AP-1 and RUNX1, that controlled expression of the wound-healing program, and found a CD161+ Treg cell signature in Crohn’s disease mucosa associated with reduced inflammation. These findings identify CD161+ Treg cells as a population involved in controlling the balance between inflammation and epithelial barrier healing in the gut.

Publication metadata

Author(s): Povoleri GAM, Nova-Lamperti E, Scotta C, Fanelli G, Chen Y-C, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun H-W, Shih H-Y, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B

Publication type: Article

Publication status: Published

Journal: Nature Immunology

Year: 2018

Volume: 19

Pages: 1403-1414

Print publication date: 01/12/2018

Online publication date: 05/11/2018

Acceptance date: 07/09/2018

ISSN (print): 1529-2908

ISSN (electronic): 1529-2916

Publisher: Nature Publishing Group


DOI: 10.1038/s41590-018-0230-z


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