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Lookup NU author(s): Sebastian Mafeld, Dr Peter Littler
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Irreversible electroporation (IRE) is a non-thermal ablative option in patients unsuitable for standard thermal ablation, due to its potential to preserve collagenous structures (vessels and ducts) and a reduced susceptibility to heat sink effects. In this series from two large tertiary referral hepatobiliary centres, we aim to assess the safety/outcomes of hepatic IRE.Bi-institutional retrospective, longitudinal follow-up series of IRE for primary hepatic malignancy; [hepatocellular carcinoma (n=20), cholangiocarcinoma (n=3)] and secondary metastatic disease; colorectal (n = 28), neuroendocrine (n = 1), pancreatic (n = 1), breast (n = 1), gastrointestinal stromal tumour (GIST, n = 1) and malignant thymoma (n = 1). Outcome measures included procedural safety/effectiveness, time to progression and time to death.Between 2013 and 2017, 52 patients underwent percutaneous IRE of 59 liver tumours in 53 sessions. All tumours were deemed unsuitable for thermal ablation. Cases were performed using ultrasound (US) or computed tomography (CT) guidance. A complete ablation was achieved in n = 44, (75%) of cases with an overall complication rate of 17% (n = 9). Of the complete ablation group, median time to progression was 8 months. At 12 months, 44% were progression-free (95% CI 30–66%). The data suggest that larger lesion size (> 2 cm) is associated with shorter time to progression and there is highly significant difference with faster time to progression in mCRC compared with HCC. Median survival time was 38 months.This bi-institutional review is the largest UK series of IRE and suggests this ablative technology can be a useful tool, but appears to mainly induce local tumour control rather than cure with HCC having better outcomes than mCRC.
Author(s): Mafeld S, Wong JJ, Kibriya N, Stenberg B, Manas D, Bassett P, Aslam T, Evans J, Littler P
Publication type: Article
Publication status: Published
Journal: CardioVascular and Interventional Radiology
Year: 2019
Volume: 42
Issue: 4
Pages: 577-583
Print publication date: 01/04/2019
Online publication date: 21/11/2018
Acceptance date: 09/11/2018
Date deposited: 23/11/2018
ISSN (print): 0174-1551
ISSN (electronic): 1432-086X
Publisher: Springer US
URL: https://doi.org/10.1007/s00270-018-2120-z
DOI: 10.1007/s00270-018-2120-z
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