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Hydrodynamics of split-rectangle-internal loop airlift bioreactor with variations in riser and downcomer cross-sectional areas based on the golden ratio

Lookup NU author(s): Professor Jarka Glassey



This is the authors' accepted manuscript of an article that has been published in its final definitive form by John Wiley & Sons Ltd, 2019.

For re-use rights please refer to the publisher's terms and conditions.


The use of bioreactors that mimic industrial reality is essential if knowledge transfer is desired. This is particularly important once filamentous microbes face harsh conditions hindering the formation of biofilms in some types of bioreactors and thus diminishing their ability to perform biotransformation or production of secondary metabolites. Airlift bioreactors can circumvent such problems; however, the lack of consensus regarding riser and downcomer partition persists. The use of golden ratio is a possibility to be considered. Our proposition was to evaluate the hydrodynamic performance and mass transfer in split-rectangle-internal loop airlift bioreactors using golden ration partition. Results: In a general way, results revealed that a partition of Ar/Ad1.618 presents better and more desirable characteristics than Ad/Ar1.618 for linear liquid velocity (UL), mixing time (tM), gas holdup (εG), liquid pressure (PL), and volumetric oxygen transfer coefficient (kLa). Such behavior was observed even when the SRILAB operated under different linear gas velocities (UG) regimens (0.5 to 1.5 vvm) and Newtonian and non-Newtonian bulk fluids. Conclusion: Such results support the idea of using golden ratio as riser-to-downcomer partitioning parameter in airlift bioreactors.

Publication metadata

Author(s): Rosa EAR, Bianchini LF, da Silva Ramos RCP, Arantes AB, da Silva RF, Glassey J

Publication type: Article

Publication status: Published

Journal: Journal of Chemical Technology & Biotechnology

Year: 2019

Volume: 94

Issue: 4

Pages: 1323-1329

Print publication date: 01/04/2019

Online publication date: 29/11/2018

Acceptance date: 22/11/2018

Date deposited: 26/11/2018

ISSN (print): 0268-2575

ISSN (electronic): 1097-4660

Publisher: John Wiley & Sons Ltd


DOI: 10.1002/jctb.5890


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