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Extreme long-term voice outcomes after concurrent chemoradiotherapy for advanced non-laryngeal head and neck cancer: Eight-year post-treatment analysis

Lookup NU author(s): Dr Charles Kelly, Dr Michael DrinnanORCiD, Professor Vinidh Paleri


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© 2018 John Wiley & Sons Ltd Background: The long-term effect of concurrent chemoradiation on voice outcomes in the context of non-laryngeal head and neck cancer is not established. Methods: A prospective, observational study to evaluate the voice quality in disease-free patients receiving concurrent chemoradiation for advanced non-laryngeal squamous cell carcinoma of the upper aerodigestive tract. Voice assessment occurred at four distinct time-points: pretreatment, 3, 12 and 92.6 months (mean) post-treatment in 34, 21 and nine patients, respectively. The authors used a combination of subjective (VoiSS questionnaire), expert rater-assessed (GRBAS scale) and acoustic analysis of the fundamental frequency to assess voice outcomes. Ethical approval was obtained from the United Kingdom National Research Ethics Service. Results: Both the VoiSS impairment and GRBAS domains continued to deteriorate over time from pre-treatment to 92.6 months post-treatment (P = 0.03). There was a strong correlation between increase in total VoiSS and GRBAS scores (r = 0.93). Acoustic analysis demonstrated no statistically significant variation in fundamental frequency. Conclusion: Radiation therapy for advanced non-laryngeal head and neck has a significant, deleterious effect on voice, which is apparent up to eight years post-treatment.

Publication metadata

Author(s): Davies-Husband C, Murphy J, Kelly C, Drinnan M, Paleri V

Publication type: Article

Publication status: Published

Journal: Clinical Otolaryngology

Year: 2018

Volume: 43

Issue: 6

Pages: 1494-1499

Print publication date: 01/12/2018

Online publication date: 01/08/2018

Acceptance date: 08/07/2018

ISSN (print): 1749-4478

ISSN (electronic): 1749-4486

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/coa.13204

PubMed id: 30066393


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