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Regulation of Endothelial-to-Mesenchymal Transition by MicroRNAs in Chronic Allograft Dysfunction

Lookup NU author(s): Emily Glover, Nina Jordan, Professor Neil Sheerin, Professor Simi Ali

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Lippincott Williams & Wilkins, 2018.

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Abstract

Fibrosis is a universal finding in chronic allograft dysfunction and is characterized by an accumulation of extracellular matrix. The precise source of the myofibroblasts responsible for matrix deposition is not understood and pharmacological strategies for prevention or treatment of fibrosis remain limited. One source of myofibroblasts in fibrosis is EndMT, a process first described in heart development. Recently, lineage tracing of endothelial cells in mouse models allowed studies of EndMT in vivo and reported 27-35% of myofibroblasts involved in cardiac fibrosis and 16% of isolated fibroblasts in bleomycin-induced pulmonary fibrosis to be of endothelial origin.Over the last decade, microRNAs have increasingly been described as key regulators of biological processes through repression or degradation of targeted mRNA. The stability and abundance of microRNAs in body fluids makes them attractive as potential biomarkers and progress is being made in developing microRNA targeted therapeutics. In this review we will discuss evidence of microRNA regulation of EndMT from in vitro and in vivo studies and the potential relevance of this to heart, lung and kidney allograft dysfunction.


Publication metadata

Author(s): Glover EK, Jordan N, Sheerin NS, Ali S

Publication type: Article

Publication status: Published

Journal: Transplantation

Year: 2018

Volume: 103

Issue: 4

Pages: e64-e73

Online publication date: 01/04/2019

Acceptance date: 09/12/2018

Date deposited: 18/12/2018

ISSN (print): 0041-1337

ISSN (electronic): 1534-6080

Publisher: Lippincott Williams & Wilkins

URL: https://doi.org/10.1097/TP.0000000000002589

DOI: 10.1097/TP.0000000000002589


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