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Lookup NU author(s): Professor Neil PerkinsORCiD
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© 2018 The Author The IκB kinase (IKK) complex is best known as the core regulator of NF-κB signalling. Recent work from Mikuda et al reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC4, a key component of the mRNA decapping complex, IKK regulates P-body formation and the stability of numerous mRNAs, including many encoding inflammatory cytokines. Activation of IKK can therefore be more generally thought of as programming the cellular response to stress and infection through both mRNA stability and transcription.
Author(s): Perkins ND
Publication type: Article
Publication status: Published
Journal: EMBO Journal
Print publication date: 14/12/2018
Online publication date: 03/12/2018
Acceptance date: 02/04/2018
ISSN (print): 0261-4189
ISSN (electronic): 1460-2075
Publisher: Wiley-Blackwell Publishing Ltd.
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