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More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription

Lookup NU author(s): Professor Neil PerkinsORCiD


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© 2018 The Author The IκB kinase (IKK) complex is best known as the core regulator of NF-κB signalling. Recent work from Mikuda et al reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC4, a key component of the mRNA decapping complex, IKK regulates P-body formation and the stability of numerous mRNAs, including many encoding inflammatory cytokines. Activation of IKK can therefore be more generally thought of as programming the cellular response to stress and infection through both mRNA stability and transcription.

Publication metadata

Author(s): Perkins ND

Publication type: Article

Publication status: Published

Journal: EMBO Journal

Year: 2018

Volume: 37

Issue: 24

Print publication date: 14/12/2018

Online publication date: 03/12/2018

Acceptance date: 02/04/2018

ISSN (print): 0261-4189

ISSN (electronic): 1460-2075

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.15252/embj.2018101084


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