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Degradation of halogenated aliphatic compounds: The role of adaptation

Lookup NU author(s): Dr Jan DolfingORCiD


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A limited number of halogenated aliphatic compounds can serve as a growth substrate for aerobic microorganisms. Such cultures have (specifically) developed a variety of enzyme systems to degrade these compounds. Dehalogenations are of critical importance. Various heavily chlorinated compounds are not easily biodegraded, although there are no obvious biochemical or thermodynamic reasons why microorganisms should not be able to grow with any halogenated compound. The very diversity of catabolic enzymes present in cultures that degrade halogenated aliphatics and the occurrence of molecular mechanisms for genetic adaptation serve as good starting points for the evolution of catabolic pathways for compounds that are currently still resistant to biodegradation.

Publication metadata

Author(s): Pries F, van der Ploeg JR, Dolfing J, Janssen DB

Publication type: Article

Publication status: Published

Journal: FEMS Microbiology Reviews

Year: 1994

Volume: 15

Issue: 2-3

Pages: 279-295

Print publication date: 01/10/1994

ISSN (print): 0168-6445

ISSN (electronic): 1574-6976

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1574-6976.1994.tb00140.x

Notes: Times Cited: 12 Cited Reference Count: 118 English Article FEMS MICROBIOL REV PP800


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