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Cardiac function is not associated with glucose control in older women

Lookup NU author(s): Dr Sarah CharmanORCiD, Dr Nduka Okwose, Dr Guy MacGowanORCiD, Professor Djordje JakovljevicORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2018 Elsevier Inc. The present study evaluated the effect of age on glucose tolerance and cardiac function and assessed the relationship between metabolic control and cardiac function and performance. Thirty-four healthy women aged 40 to 81 years were divided into two age groups: younger (≤50 years of age, N = 19) and older (≥60 years of age, N = 15). Participants performed an oral glucose tolerance test and a graded cardiopulmonary exercise test with non-invasive haemodynamic measurements. Compared to younger, older women demonstrated significantly higher 2-hour glucose (4.67 ± 1.01 vs 6.08 ± 1.54 mmol/l, P < 0.01), but lower peak exercise O2 consumption (1.96 ± 0.44 vs 1.38 ± 0.26 l/min, P < 0.01) and cardiac power output (4.06 ± 0.76 vs 3.35 ± 0.73 W, P = 0.01). When data from all study participants were combined, there was a significant negative relationship between 2-hour glucose and peak cardiac power (r = −0.39, P = 0.02), and peak O2 consumption (r = −0.40, P = 0.02). The strength of these relationships was affected by age, with moderate negative relationship identified between 2-hour glucose and peak cardiac power output in younger compared to older participants (r = −0.38, P = 0.11 vs. r = −0.09, P = 0.75). Metabolic control and cardiac function decline with age. The lack of relationship between glucose control and cardiac power may suggest that metabolic control does not influence cardiac function and performance in older women.

Publication metadata

Author(s): Jones C, Markovic M, Charman S, Okwose N, Ivkovic S, Ropret R, Markovic B, Mandaric S, Grbovic M, MacGowan GA, Jakovljevic DG

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2019

Volume: 116

Pages: 31-36

Print publication date: 01/02/2019

Online publication date: 20/12/2018

Acceptance date: 19/12/2018

Date deposited: 01/02/2019

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier Inc.


DOI: 10.1016/j.exger.2018.12.014


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777204Commission of the European Communities