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Lookup NU author(s): Dr David Woods
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© 2018 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. The binding of high-mobility group box-1 (HMGB-1) to the membrane receptor for advanced glycation end-products (mRAGE) is a key early mediator of non-infectious inflammation and its triggers include ischaemia/hypoxia. The effects of acute hypoxia on soluble RAGE (sRAGE) are unknown. Fourteen healthy adults (50 % women; 26.6 ± 3.8 years) were assessed at baseline normoxia (T0), followed by four time-points (T90, 95, 100 and 180 min) over three hours of continuous normobaric hypoxia (NH, 4,450 m equivalent) and again 60 min after return to normoxia (T240). A 5-min exercise step test was performed during NH at T90. Plasma concentrations of HMGB-1, sRAGE VCAM-1, ICAM-1, VEGF IL-8 and IL-13 were measured using venous blood. Arterial and tissue oxygen saturations were measured using pulse oximetry (SpO2) and near-infrared spectroscopy (StO2), respectively. NH led to a significant reduction in SpO2, StO2, sRAGE and VEGF, which was compounded by exercise, before increasing to baseline values with normoxic restoration (T240). NH-exercise led to a paired increase in HMGB-1. sRAGE inversely correlated with HMGB-1 (r = -0.32; p = 0.006), heart rate (r = -0.43; p = 0.004) but was not linked to SpO2 or StO2. In conclusion, short-term NH leads to a fall in sRAGE and VEGF concentrations with a transient rise post NH-exercise in HMGB-1.
Author(s): Boos CJ, Lamb CM, Midwinter M, Mellor A, Woods DR, Howley M, Stansfield T, Foster M, O'Hara JP
Publication type: Article
Publication status: Published
Journal: Physiological Research
Print publication date: 01/12/2018
Online publication date: 10/05/2018
Acceptance date: 02/04/2018
ISSN (print): 0862-8408
ISSN (electronic): 1802-9973
Publisher: Czech Academy of Sciences
PubMed id: 29750887