Lookup NU author(s): Professor Roger Whittaker,
Dr Paola Porcari,
Dr Luis Braz,
Dr Ian Schofield,
Professor Andrew Blamire
This is the authors' accepted manuscript of an article that has been published in its final definitive form by John Wiley & Sons, Inc., 2019.
For re-use rights please refer to the publisher's terms and conditions.
A novel diffusion-weighted MRI protocol sensitive to contraction of individual skeletal motor units was developed. We applied this technique to the lower limb muscles of 4 patients with confirmed ALS and six healthy controls. A 3-minute scan revealed florid fasciculation in ALS patients, involving both superficial and deep muscles, and at a frequency higher than in healthy controls. This novel imaging technique reveals hitherto unobtainable information on human motor unit structure and function, which may allow earlier diagnosis and recruitment to clinical trials.
Author(s): Whittaker RG, Porcari P, Braz L, Williams TL, Schofield IS, Blamire A
Publication type: Article
Publication status: Published
Journal: Annals of Neurology
Online publication date: 28/01/2019
Acceptance date: 21/01/2019
Date deposited: 23/01/2019
ISSN (print): 0364-5134
ISSN (electronic): 1531-8249
Publisher: John Wiley & Sons, Inc.
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