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Calorie restriction for long-term remission of type 2 diabetes

Lookup NU author(s): Professor Roy Taylor


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© Royal College of Physicians 2019. All rights reserved. Starting with a hypothesis which postulated a simple explanation arising from the basic cause of type 2 diabetes, a series of studies has introduced a paradigm shift in our understanding of the condition. Gradual accumulation of fat in the liver and pancreas leads eventually to beta cell dedifferentiation and loss of specialised function. The consequent hyperglycaemia can be returned to normal by removing the excess fat from liver and pancreas. At present this can be achieved only by substantial weight loss, and a simple practical and efficacious method for this has been developed and applied in a series of studies. For those people who used to have type 2 diabetes, the state of post-diabetes can be long term provided that weight regain is avoided. The implications for personal health and for national health economics are considerable.

Publication metadata

Author(s): Taylor R

Publication type: Review

Publication status: Published

Journal: Clinical Medicine

Year: 2019

Volume: 19

Issue: 1

Pages: 37-42

Online publication date: 01/01/2019

Acceptance date: 02/04/2018

ISSN (print): 1470-2118

ISSN (electronic): 1473-4893

Publisher: Royal College of Physicians


DOI: 10.7861/clinmedicine.19-1-37

PubMed id: 30651243