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The Enigmatic Esx Proteins: Looking Beyond Mycobacteria

Lookup NU author(s): Professor Tracy Palmer FRS FRSE FMedSciORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2016 Elsevier Ltd Bacteria export proteins across membranes using a range of transport machineries. Type VII secretion systems (T7SSs), originally described in mycobacteria, are now known to be widespread across diverse bacterial phyla. Recent studies have characterized secretion components and mechanisms of type VII secretion in pathogenic and environmental bacteria. A variety of functions have been attributed to T7SS substrates, including interactions with eukaryotes and with other bacteria. Here, we evaluate the growing body of knowledge on T7SSs, with focus on the nonmycobacterial systems, reviewing their phylogenetic distribution, structure and function in diverse settings.

Publication metadata

Author(s): Unnikrishnan M, Constantinidou C, Palmer T, Pallen MJ

Publication type: Review

Publication status: Published

Journal: Trends in Microbiology

Year: 2017

Volume: 25

Issue: 3

Pages: 192-204

Print publication date: 01/03/2017

Online publication date: 25/11/2016

Acceptance date: 02/04/2016

ISSN (print): 0966-842X

ISSN (electronic): 1878-4380

Publisher: Elsevier Ltd


DOI: 10.1016/j.tim.2016.11.004

PubMed id: 27894646