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Lookup NU author(s): Professor Tracy Palmer FRS FRSE FMedSciORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2016 Elsevier Ltd Bacteria export proteins across membranes using a range of transport machineries. Type VII secretion systems (T7SSs), originally described in mycobacteria, are now known to be widespread across diverse bacterial phyla. Recent studies have characterized secretion components and mechanisms of type VII secretion in pathogenic and environmental bacteria. A variety of functions have been attributed to T7SS substrates, including interactions with eukaryotes and with other bacteria. Here, we evaluate the growing body of knowledge on T7SSs, with focus on the nonmycobacterial systems, reviewing their phylogenetic distribution, structure and function in diverse settings.
Author(s): Unnikrishnan M, Constantinidou C, Palmer T, Pallen MJ
Publication type: Review
Publication status: Published
Journal: Trends in Microbiology
Print publication date: 01/03/2017
Online publication date: 25/11/2016
Acceptance date: 02/04/2016
ISSN (print): 0966-842X
ISSN (electronic): 1878-4380
Publisher: Elsevier Ltd
PubMed id: 27894646