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High-speed imaging of ultrasound-mediated bacterial Biofilm Disruption

Lookup NU author(s): Professor Tracy Palmer FRS FRSE FMedSciORCiD


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© Springer International Publishing Switzerland 2015.Bacterial biofilms are common roots of persistent infections. Their structure provides for increased resistance against anti-microbial agents, making them difficult to treat and eradicate. The introduction of ultrasound and microbubble provides the prospect of non-invasive treatment of bacterial biofilms. We adopt the use of a high-speed imaging and optical trapping setup to study the physical mechanisms of ultrasound-mediated microbubble disruption of bacterial biofilms. It was found that the bacterial biofilms could be effectively disrupted due to cavitation collapse of a neighbouring microbubble. However, the efficacy of biofilm disruption depends on several parameters such as stand-off distance and ultrasound parameters.

Publication metadata

Author(s): Goh BHT, Conneely M, Kneuper H, Palmer T, Klaseboer E, Khoo BC, Campbell P

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 6th European Conference of the International Federation for Medical and Biological Engineering

Year of Conference: 2014

Pages: 533-536

Acceptance date: 01/01/1900

Publisher: Springer Verlag


DOI: 10.1007/978-3-319-11128-5_133

Library holdings: Search Newcastle University Library for this item

ISBN: 9783319111278