Toggle Main Menu Toggle Search

Open Access padlockePrints

Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390

Lookup NU author(s): Dr Guillermina Casabona, Professor Tracy Palmer FRS FRSE FMedSciORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 The Authors. The Staphylococcus aureus type VII protein secretion system (T7SS) plays important roles in virulence and intra-species competition. Here we show that the T7SS in strain RN6390 is activated by supplementing the growth medium with haemoglobin, and its cofactor haemin (haem B). Transcript analysis and secretion assays suggest that activation by haemin occurs at a transcriptional and a post-translational level. Loss of T7 secretion activity by deletion of essC results in upregulation of genes required for iron acquisition. Taken together these findings suggest that the T7SS plays a role in iron homeostasis in at least some S. aureus strains.

Publication metadata

Author(s): Casabona MG, Kneuper H, de Lima DA, Harkins CP, Zoltner M, Hjerde E, Holden MTG, Palmer T

Publication type: Article

Publication status: Published

Journal: Microbiology

Year: 2017

Volume: 163

Issue: 12

Pages: 1839-1850

Print publication date: 01/12/2017

Online publication date: 24/11/2017

Acceptance date: 14/11/2017

Date deposited: 14/02/2019

ISSN (print): 1350-0872

ISSN (electronic): 1465-2080

Publisher: Microbiology Society


DOI: 10.1099/mic.0.000579

PubMed id: 29171824


Altmetrics provided by Altmetric


Funder referenceFunder name