Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Translating the Hypoxic Response—the Role of HIF Protein Translation in the Cellular Response to Low Oxygen

Lookup NU author(s): Dr Iglika Ivanova, Dr Catherine Park, Dr Niall Kenneth

Downloads

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Hypoxia-Inducible Factors (HIFs) play essential roles in the physiological response to low oxygen in all multicellular organisms, while their deregulation is associated with human diseases. HIF levels and activity are primarily controlled by the availability of the oxygen-sensitive HIFα subunits, which is mediated by rapid alterations to the rates of HIFα protein production and degradation. While the pathways that control HIFα degradation are understood in great detail, much less is known about the targeted control of HIFα protein synthesis and what role this has in controlling HIF activity during the hypoxic response. This review will focus on the signalling pathways and RNA binding proteins that modulate HIFα mRNA half-life and/or translation rate, and their contribution to hypoxia-associated diseases.

Publication metadata

Author(s): Ivanova IG, Park CV, Kenneth NS

Publication type: Review

Publication status: Published

Journal: Cells

Year: 2019

Volume: 8

Issue: 2

Online publication date: 01/02/2019

Acceptance date: 03/01/2019

ISSN (print): 2073-4409

ISSN (electronic): 2073-4409

URL: https://doi.org/10.3390/cells8020114

DOI: 10.3390/cells8020114

Share